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Position: Home > Faculty & staff > Faculty-PhD. Supervisor > Content     

Name:Yoshinori Marunaka

Professor

Address:67 Kitatsuboi-cho, Nishinokyo, Nakagyo-ku, Kyoto 604-8472, Japan

Phone:+81-75****310

Fax:+81-75****125
E-mail:marunaka@koto.kpu-m.ac.jp
Websites:/info/1075/4712.htm
Education

1979        M.D.    Medicine        Kyoto Prefectural University of Medicine
1985      Ph.D.    Physiology    Kyoto Prefectural University of Medicine

Professional Experience

2018 - present        The Representative Director,
   Kyoto Industrial Health Association

2018 - present        The Vice President,
Kyoto Industrial Health Association

2018 - present        The Director,
Clinic, Kyoto Industrial Health Association

2018 – present      The Director,
Research Institute for Clinical Physiology,
Kyoto Industrial Health Association

2018 – present     Professor,
Research Center for Drug Discovery and Pharmaceutical Development Science,
Research Organization of Science and Technology, Ritsumeikan University

2016 - present        The President,  
The Physiological Society of Japan

2015 - 2017    Director
   Center for Information and Multimedia Studies
   Kyoto Prefectural University of Medicine

2013 - 2018    Professor and Chairman
   Department of Bio-Ionomics
   Graduate School of Medical Science
   Kyoto Prefectural University of Medicine

2013 - present    Adjunct Professor
   Department of Respiratory Medicine
   Fudan University
   Shanghai Respiratory Research Institute

2011 - present    Professor and Director
   Japan Institute for Food Education and Health
   St. Agnes’ University

     2007 - 2017    Director
   Center for Medical Education and Research
Kyoto Prefectural University of Medicine

2003 - 2018    Professor and Chairman
   Department of Molecular Cell Physiology
   Graduate School of Medical Science
   Kyoto Prefectural University of Medicine

   2003 - 2010    Professor and Chairman
   Department of Respiratory Medicine
   Graduate School of Medical Science
   Kyoto Prefectural University of Medicine

   2003 - 2007    Professor and Chairman
   Department of Biochemistry and Molecular Genetics
   Research Institute for Neurological Diseases & Geriatrics
   Kyoto Prefectural University of Medicine

   2000 - 2003    Professor and Chairman
   Department of Cellular and Molecular Physiology
   School of Medicine
   Kyoto Prefectural University of Medicine

   

   1992 - 2000    Associate Professor
   Institute of Medical Science
   The University of Toronto

   1992 - 2000    Associate Professor
   Division of Respiratory Medicine
   Department of Pediatrics
   The University of Toronto Faculty of Medicine

   1991 - 1992    Assistant Professor
   Division of Respiratory Research
   (Lung Biology Programme)
   Research Institute
   The Hospital for Sick Children
   The University of Toronto

   1988 - 1990    Assistant Professor of Physiology
   Emory University School of Medicine

   1986 – 1988    Associate
   Department of Physiology
   Emory University School of Medicine

   1986 - 1986    Research Associate
   Department of Physiology and Biophysics
   University of Texas Medical Branch at Galveston

   1985 - 1986    Instructor
   Department of Physiology
   Shiga University of Medical Science


Scientific Research Field

1. Food nutrition and health evaluation
2. Ion epithelial transmission control mechanism caused by hormone and osmotic pressure
3. Cancer cell growth control mechanism
4. Neural regeneration mechanism
5. Biological activity of chloride ions

Social academic post and honor

   The Premier's Research Excellence Award (1999)
   The Government of Ontario

   Marco Polo della Scienza Italiana  (2013)?
   Italian Government

Teaching Courses

Medical Physiology
Membrane Transport


Published papers

Has published more than two hundred papers. The representative researches can be listed as follows:


1. Puppulin P, Hosogi S, Sun H, Matsuo K, Inui T, Kumamoto Y, Suzaki T, Tanaka H, MARUNAKA Y
Bioconjugation strategy for cell surface labelling with gold nanostructures designed for highly localized pH measurement
Nature Communications 9(1) 5278, 2018

2. MARUNAKA Y, Niisato N, Taruno A, Ohta M, Miyazaki M, Hosogi S, Nakajima K, Kusuzaki K, Ashihara E, Nishio K, Iwasaki Y, Nakahari T, Kubota T.
Regulation of epithelial sodium transport via epithelial Na+ channel (ENaC)
J Biomed Biotechnol 2011:978196, 2011

3. MARUNAKA Y, Yoshimoto K, Aoi W, Hosogi S, Ikegaya H
Low pH of interstitial fluid around hippocampus of the brain in diabetic OLETF rats
Molecular and Cellular Therapies 2:6, 2014

4. MARUNAKA Y
Roles of ionic environments in growth of human cancer cell and potentials of ion transporter blockers in cancer therapies
J Gastrointestinal and Digestive System 3:163, 2014

5. MARUNAKA Y
Importance of expression and function of angiotensin II receptor type 1 in pulmonary epithelial cells?
Respiratory Physiol Neurobiol 196:39-42, 2014

6. MARUNAKA Y
Characteristics and pharmacological regulation of epithelial Na+ channel (ENaC) and epithelial Na+ transport
J Pharmacol Sci 126:21-36, 2014

7. MARUNAKA Y
Roles of interstitial fluid pH in diabetes mellitus: Glycolysis and mitochondrial function
World J Diabetes 6:125-135, 2015

8. MARUNAKA Y, Niisato N, Miyazaki H, Nakajima K, Taruno A, Sun H, Marunaka R, Okui M, Yamamoto T, Kanamura N, Kogiso H, Ikeuchi Y, Kashio M, Hosogi S, Nakahari T
Quercetin is a useful medicinal compound showing various actions including control of blood pressure, neurite elongation and epithelial ion transport
Current Med Chem 23:1-12, 2016
9. MARUNAKA Y, Marunaka R, Sun H, Yamamoto T, Kanamura N, Taruno A
Na+ homeostasis by epithelial Na+ channel (ENaC) and Nax channel (Nax): cooperation of ENaC and Nax
Annals of Translational Medicine 4 (Suppl 1):S11, 2016.

10. MARUNAKA Y, Marunaka R, Sun H, Yamamoto T, Kanamura N, Inui T, Taruno A.
Actions of quercetin, a polyphenol, on blood pressure.
Molecules 22(2). pii: E209, 2017.

11. MARUNAKA Y
Actions of quercetin, a flavonoid, on ion transporters: its physiological roles
Annals of the New York Academy of Sciences 1398(1):142-151, 2017

12. MARUNAKA Y.
The mechanistic links between insulin and cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel
Int J Mol Sci 18(8): pii: E1767, 2017

13. MARUNAKA Y
The proposal of molecular mechanisms of weak organic acids intake-induced improvement of insulin resistance in diabetes mellitus via elevation of interstitial fluid pH
Int J Mol Sci 19(10):3244, 2018

Main Scientific Research Projects

Four-University Collaborative Research Grant
Development of new system for drug delivery specific to cancer cells (2012 - 2013)?
?1,150,000

Japan Society of The Promotion of Science
Clarification of tumor metastatic mechanism caused by disturbance of WNK kinase-dependent Cl- transporter (2013-2016)
?5,200,000

Japan Society of The Promotion of Science
Continuous pH measurement of interstitial fluid and clarification of pathogenic mechanism of insulin resistance by ISFET pH sensor (2013-2015)
?3,770,000

KIT-KPUM-KPU-KPhU Collaborative Research Grant
Molecular cell mechanisms of interstitial pH-mediated appearance of insulin resistance in diabetes mellitus (2013 - 2014)?
?2,000,000

Yamada Research Grant
The prevention of Alzheimer’s disease and its complications through the improvement of interstitial pH by propolis intake (2013 - 2014)
?4,900,000

Japan Society of The Promotion of Science
New targeting mechanisms of plasma proteins to proteasome (2015-2018)
?4,940,000


Japan Society of The Promotion of Science
Development of non-invasive methods measuring interstitial fluid pH and HCO3- concentration by MRI and Raman (2015-2017)
?3,770,000

Kyoto-Funding for Innovation in Health-related R&D Fields
Development of apparatus measuring interstitial fluid pH as a biomarker for early diagnosis of type 2 diabetes and Alzheimer's dementia (2015-2016)
?1,300,000

KIT-KPUM-KPU-KPhU Collaborative Research Grant
Roles of interstitial fluid pH in development for type 2 diabetes and the Alzheimer's dementia and molecular mechanisms of regulation of interstitial fluid (2015 - 2016)?
?2,000,000

Japan Society of The Promotion of Science
Prevention of diabetes mellitus and Alzheimer dementia via improvement of low interstitial fluid pH by food constituent (2018-2021)
?17,420,000


Patents

Medical light irradiation device  JP 5702529 B2  2015.4.15

Scientific Research Achievements and Awards

   Research Fellowship Abroad (1986 - 1988)
   Ministry of Education, Science and Culture of Japan

   Research Award (1989)
   The National Kidney Foundation of U.S.A.

   Scholarship (1991 - 1996)
   Medical Research Council of Canada

   Research Scholarship (1991 - 1996)
   Heart and Stroke Foundation of Ontario

Number of postgraduates under supervision
44

Number of supervised masters and Ph.D.
52

Number of supervised undergraduates
154

The above information updated
Sep.29, 2019
    


 

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